Cleo Integration

Integrate your digital health solution with CLEO using 6B’s secure, standards-based healthcare interoperability services. We connect primary care systems, NHS 111 services, ambulance platforms, electronic patient records, electronic prescribing services, diagnostics, patient-facing applications, and analytics tools with CLEO – enabling reliable data exchange across urgent, emergency, outpatient, and community care pathways.

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Trusted by NHS organisations, urgent care providers, and healthtech innovators, 6B delivers full-lifecycle CLEO integration, from discovery and architecture to development, testing, deployment, and support. We build secure, scalable integrations for digital triage, virtual waiting rooms, clinical records, electronic prescribing, patient tracking, discharge, and operational reporting.

Our team combines urgent care workflow expertise with HL7 FHIR, HL7 messaging, REST APIs, NHS Spine services, identity management, event-driven integration, and clinical safety. Solutions are designed for time-critical workflows, data integrity, patient-flow visibility, and safe transfers between services.

Understanding CLEO

CLEO Systems provides digital platforms for urgent care, emergency care, outpatient services, community pharmacy, and other out-of-hospital settings.

CLEO Urgent Care manages pathways from initial contact through assessment, treatment, discharge, or referral, supporting services such as NHS 111, clinical assessment, out-of-hours care, urgent treatment centres, and neighbourhood services.

CLEO CORE is a configurable patient management platform connecting entry routes including NHS 111, NHS 111 Online, general practice, and walk-ins with coordinated assessment and treatment pathways.

CLEO EPS supports electronic prescribing in outpatient and community settings, transferring prescriptions to nominated pharmacies. CLEO SOLO EPS can operate independently or within an integrated clinical workflow.

CLEO can also integrate with primary care and shared care platforms, including EMIS, helping clinicians access information and update records during urgent care encounters.

Our CLEO Integration Process

We begin with structured discovery involving clinical, prescribing, operational, digital, technical, and governance stakeholders. We define pathways, users, data requirements, safety constraints, and intended outcomes.

Typical integrations include NHS 111 referrals, demographic synchronisation, primary care record access, patient tracking, diagnostics, prescribing, discharge, and operational reporting.

We map patient identities, encounters, referrals, triage data, observations, assessments, diagnoses, medicines, investigations, outcomes, and onward referrals. Particular attention is given to NHS numbers, temporary identifiers, duplicate records, and encounters spanning multiple providers.

Architecture may use FHIR, REST APIs, HL7 messages, integration engines, NHS Spine interfaces, contextual launch, or event-driven messaging. Authentication can support OAuth 2.0, OpenID Connect, NHS CIS2, single sign-on, service accounts, and role-based access.

Reusable integration components accelerate delivery, while secure testing validates patient matching, prescribing, permissions, audit, performance, failure recovery, and downtime reconciliation.

Before launch, we coordinate acceptance testing, clinical safety review, deployment, training, and documentation. After go-live, we monitor data flows, resolve issues, and maintain compatibility with CLEO and NHS changes.

Benefits of CLEO Integration

Clinicians gain access to more complete information within existing workflows, while operational teams improve visibility of demand, waiting times, pathway stages, workload, prescribing, and outcomes.

Connected services support smoother referrals, callbacks, bookings, transfers, electronic prescribing, and discharge communication. Patients benefit from less repetition, faster access to medicines, fewer unnecessary redirects, and better-informed decisions.

Providers gain stronger continuity, resilience, and business intelligence. Healthtech vendors gain reusable access to established urgent care, outpatient, and community workflows across multiple NHS organisations.

Why Choose 6B for CLEO Integration?

6B designs around the complete urgent care pathway, keeping information accurate and traceable throughout the patient journey.


Our specialists understand HL7 FHIR, HL7 v2, APIs, NHS Spine services, integration engines, and event-driven messaging.


We address complex identity and workflow challenges, including temporary registrations, repeated contacts, patient merges, transfers, and multi-channel care.


Our prescribing integrations support dm+d, identifiers, pharmacy nomination, prescription status, cancellation, authorisation, and audit trails.


Security and privacy are embedded through encryption, role-based access, permissions, audit logging, data minimisation, and sensitive-information controls.


We support DCB0129 and DCB0160 responsibilities through hazard management, validation, alerting, reconciliation, downtime procedures, and operational controls.


From discovery to maintenance, 6B provides one accountable, multidisciplinary integration partner for dependable use in live NHS environments.

Estimate the Cost of Your Cleo Integration Project

Please answer a few questions to help our Cleo integration consultants accurately assess your needs and calculate a personalised quote quicker.

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Cleo integration FAQs

CLEO is a suite of digital healthcare solutions for urgent care, integrated care, outpatient services, and community prescribing. Its products include CLEO Urgent Care, CLEO UTC, CLEO CAS, virtual waiting-room tools, and CLEO EPS.

Yes. CLEO is designed to connect with primary care records, shared care services, NHS 111, digital triage tools, prescribing services, and other clinical platforms. Available interfaces depend on the deployed CLEO modules and local configuration.

An integration may exchange patient demographics, NHS 111 referrals, presenting symptoms, appointments, triage details, clinical notes, medicines, prescriptions, care outcomes, discharge information, and operational status updates.

Yes. CLEO Urgent Care and CLEO UTC can support NHS 111 bookings and referral workflows. CLEO has also integrated NHS Pathways digital streaming so recorded symptoms can transfer directly into the urgent treatment centre workflow.

Yes. CLEO supports interoperability with GP and Care Connect services, helping authorised clinicians access relevant patient information during an urgent-care encounter. Specific access depends on local information-sharing and technical arrangements.

Yes. CLEO EPS enables authorised clinicians in outpatient, community, and urgent-care settings to create prescriptions and send them electronically to the patient’s nominated community pharmacy.

We use patient-matching controls, data validation, role-based access, audit trails, prescription-status checks, exception handling, reconciliation, downtime procedures, and structured clinical testing. We also support applicable DCB0129 and DCB0160 responsibilities.

Timescales depend on the CLEO modules, required workflows, available interfaces, NHS service connections, data mappings, supplier coordination, governance approvals, and testing scope. A focused interface may take several weeks, while a wider urgent-care integration programme may take several months.

Readiness checklist for CLEO Integration

  • Define the pathways and use cases your integration will support, such as NHS 111 referrals, urgent care patient management, virtual waiting rooms, primary care record access, prescribing, discharge, or analytics.
  • Identify the CLEO CORE, CLEO Urgent Care, CLEO EPS, primary care, NHS 111, ambulance, EPR, laboratory, radiology, pharmacy, and third-party systems involved.
  • Confirm which FHIR resources, HL7 messages, RESTful APIs, NHS Spine services, document interfaces, or integration-engine connections are available within the target deployment.
  • Map patient identifiers, referral references, appointments, encounters, triage information, observations, clinical notes, medicines, prescriptions, outcomes, and discharge information across connected systems.
  • Define which system will act as the source of truth for demographics, referrals, encounter status, clinical documentation, prescribing information, and discharge records.
  • Confirm how temporary registrations, unknown patients, duplicate referrals, repeated contacts, patient merges, and retrospective demographic corrections will be reconciled.
  • Where CLEO EPS is involved, confirm dm+d mapping, prescriber identity, organisation codes, pharmacy nomination, electronic prescription status, cancellation, and audit requirements.
  • Document authentication, authorisation, NHS CIS2, single sign-on, role-based access, emergency access, encryption, service-account, and audit-logging requirements.
  • Prepare governance and clinical safety documentation, including the lawful basis, DPIA, DSPT position, and applicable DCB0129 or DCB0160 responsibilities.
  • Develop a testing plan covering synthetic data, NHS 111 referrals, temporary identifiers, unavailable primary care records, failed prescriptions, duplicate contacts, delayed messages, downtime, peak activity, and clinical user acceptance.
  • Agree deployment, training, monitoring, incident management, supplier coordination, interface change control, contingency arrangements, upgrades, and ongoing support before production go-live.

Speak To Our Cleo Integration Experts

Whether you're developing a new digital health product or extending an existing solution with Cleo integration, 6B brings the technical expertise, healthcare insight, and experience needed to accelerate delivery.

Rebecca Willis

Rebecca Willis

Business Development

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Or call Rebecca on 0113 350 1290