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NHS Spine Integration

Integrate your digital health application with NHS Spine services using 6B’s secure, compliant, and proven integration expertise. We enable access to national NHS infrastructure, supporting integration with key services including the Electronic Prescription Service (EPS), Summary Care Record (SCR), e-Referrals Service (e-RS), and the Personal Demographics Service (PDS).

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Whether you're developing a new digital health product or extending an existing solution with NHS Spine integration, 6B brings the technical expertise, healthcare insight, and experience needed to accelerate delivery.

Rebecca

Rebecca

Business Development

Or call Rebecca on 0113 350 1290

As specialists in NHS Spine integration, we help digital health innovators and NHS organisations connect to the national spine through structured, standards-aligned development – ensuring interoperability, governance compliance, and long-term sustainability.

Understanding NHS Spine

NHS Spine 2 is the core national IT infrastructure that underpins digital health and social care services in England. It enables secure, standardised exchange of patient information between more than 20,500 organisations and over 23,000 healthcare systems.

Spine 2 powers many critical services, including:

Integration with Spine 2 requires adherence to national interoperability and security standards. 6B helps organisations navigate this complexity and build integrations that are secure, scalable, and ready for deployment across the NHS.

Spine Mini Service Provider (SMSP) Integration

The Spine Mini Service Provider (SMSP) is a lightweight, read-only interface that provides secure access to Spine 2 data via the Interoperability Toolkit (ITK). It allows applications to retrieve demographic and core patient data without needing full Spine infrastructure access.

6B develops SMSP integrations tailored to your application’s needs, supporting identity verification, demographics lookups, and care coordination workflows. We also offer consultancy support for completing the required onboarding documentation, including ITK conformance packs and assurance guidance.

NHS Spine 2 Test Environment

Following development, 6B conducts thorough integration testing using the NHS Digital Opentest environment. This open-access, Spine-aligned test infrastructure hosts live-like instances of:

  • NHS Spine Core
  • Personal Demographics Service (PDS)
  • Electronic Prescription Service (EPS)
  • Personal Spine Information Service (PSIS)

We use Opentest to simulate real integration scenarios, validate interoperability, and ensure your solution performs as expected within the NHS ecosystem. It also provides a powerful platform for demonstrating functionality to prospective NHS customers and stakeholders.

Benefits of NHS Spine Integration

Integrating your application with Spine 2 enables access to a wide range of national services that power the NHS’s digital operations. Whether verifying patient identity, retrieving core demographics, processing prescriptions, or initiating referrals, Spine integration ensures secure access to the data needed for joined-up, high-quality care.

By building to Spine 2 standards, your product becomes more interoperable, easier to deploy at scale, and more appealing to NHS customers. Integration also supports alignment with NHS England’s digital transformation strategy, enabling trusted, safe, and timely data sharing across the health and care system.

Why Choose 6B for NHS Spine Integration?

We have delivered integrations with key Spine services and are experienced in developing secure, scalable applications using SMSP, EPS, PDS, and other Spine-enabled APIs.


6B has worked with both public sector healthcare organisations and private digital health startups, supporting projects from proof-of-concept to full-scale deployment.


We are familiar with core NHS interoperability tools including MESH, NHS Login, and Spine Directory Services. We also integrate with leading clinical systems such as SystmOne, EMIS, and System C.


We are ISO 27001 certified, Cyber Essentials compliant, and experienced in working with sensitive health data in line with NHS and global standards including NHS DSPT, DTAC, HIPAA, and CFR Part 11. Our team works with healthcare data models including SNOMED CT, HL7 FHIR, openEHR, and CDM.


From planning and architecture to development, testing, onboarding, and go-live, we offer a full-service integration model. Our consultants handle communication with NHS Digital and manage assurance processes on your behalf to accelerate delivery and reduce risk.

NHS Spine Integration FAQs

NHS Spine integration requires strict adherence to national security protocols to protect sensitive patient data. Systems must comply with Warranted Environment Specification (WES), use approved authentication (like NHS Smartcards or modern equivalents), and communicate via encrypted channels such as TLS. When working through the Spine Secure Proxy (SSP), developers benefit from a centrally managed trust model, reducing the complexity of endpoint authentication while maintaining high levels of access control and auditability.

The Spine Secure Proxy acts as a trusted intermediary that simplifies connectivity and enhances security for NHS Spine integration. It allows systems to communicate without opening inbound firewall rules to all potential NHS partners. SSP also streamlines system authorisation, supports centralised performance monitoring, and enables rapid incident isolation. For digital health products, this reduces infrastructure overhead while ensuring compliance and scalability.

Synchronous messaging is used when a system requires an immediate response from Spine services (e.g., patient demographic lookups). In contrast, asynchronous messaging — enabled by MESH (Message Exchange for Social Care and Health) — supports queued, store-and-forward data transfers, ideal for high-volume or batch processing use cases. Choosing the right pattern is critical for performance, user experience, and conformance with NHS use case guidelines.

Third-party applications cannot typically access NHS Spine directly. Instead, they must integrate via approved intermediaries or be onboarded as an accredited system through NHS Digital’s assurance process. Using frameworks like SMSP (Spine Mini Service Provider), digital health vendors can securely query demographic data without full Spine access, making it easier to integrate while still benefiting from the core infrastructure.

NHS Digital offers the Opentest environment, a fully featured, live-like test environment for developers integrating with Spine services. It includes emulated versions of PDS, EPS, and other Spine endpoints, allowing teams to validate functionality, performance, and interoperability before live deployment. 6B supports clients throughout the test process, including managing test data, test harness configuration, and assurance pack preparation.

Several national programmes are underpinned by NHS Spine integration, including GP Connect, the National Care Records Service (NCRS), Electronic Prescription Service (EPS), and Summary Care Record (SCR). Each leverages Spine’s infrastructure for secure, standardised data sharing across care settings. Emerging programmes, such as those using FHIR APIs via SSP, are also expanding Spine’s utility across primary, secondary, and community care.

FHIR APIs offer a more modern, flexible, and standardised approach to NHS Spine integration compared to legacy SOAP or proprietary APIs. They simplify data exchange, improve developer experience, and support real-time access to structured data. NHS England is increasingly prioritising FHIR-based integrations to improve interoperability, and the Spine Secure Proxy is central to securely exposing these APIs to external systems.

NHS Spine integration directly supports the NHS’s Long Term Plan by enabling safe, real-time data sharing across care settings. It improves continuity of care, enhances patient safety, and empowers digital-first services. For innovators, integrating with Spine means their products can contribute to joined-up care, interoperability, and better population health outcomes — all key pillars of the NHS’s digital transformation agenda.