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NHS Electronic Prescription Service (EPS) API Integration

Integrating with the NHS Electronic Prescription Service (EPS) through its modern FHIR API enables healthcare providers, pharmacies, and digital health innovators to streamline the end-to-end prescription journey.

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Need help with NHS Electronic Prescription Service (EPS) API Integration?

Whether you're developing a new digital health product or extending an existing solution with NHS Electronic Prescription Service (EPS) API integration, 6B brings the technical expertise, healthcare insight, and experience needed to accelerate delivery.

Rebecca

Rebecca

Business Development

Or call Rebecca on 0113 350 1290

At 6B, we support health tech companies and healthcare organisations through the full EPS integration lifecycle. From initial onboarding and use case planning to FHIR API development, assurance, and go-live, we provide the technical expertise and project leadership needed to successfully connect to the EPS ecosystem. Our experience spans primary and secondary care settings, enabling us to accelerate the integration process and ensure compliance with NHS standards at every step.

Understanding NHS EPS FHIR Integration

The NHS EPS FHIR API is the modern, FHIR‑based interface for sending and managing electronic prescriptions in England. It enables prescribers in primary and secondary care to create, encode, cancel, and transmit prescriptions directly to patient-nominated pharmacies; dispensers can retrieve, return, notify dispenses, and submit claims – all without manual paperwork.

The API supports both prescribing and dispensing use cases and integrates with supplementary services such as the Directory of Services (DoS) API and Prescription Tracker. It replaces the legacy HL7 V3 interface, allowing secure OAuth‑authenticated access and sandbox testing environments.

Our NHS EPS API Integration Process

6B supports your EPS integration from initial onboarding through live deployment:

We start by defining your use case and assisting with submission of the EPS Use Case form to enter the onboarding queue.

Once accepted, we guide you through MoU signing, and tiered onboarding – from sandbox testing to first-of-type live monitoring and full deployment, typically completed in approximately 18 months .

Our development team builds against the EPS FHIR API, Model APIs, and Prescription Tracking API, ensuring compliance with the SCAL and NHS clinical safety standards. We also set up DoS service lookup using OAuth‑secured REST endpoints.

We conduct sandbox testing, live environment trials, and monitored production rollouts. Once signed off, EPS systems receive a Clinical Authority to Release (CATR) and are cleared for full deployment.

We remain on hand for post-launch support, prescription status tracking, and iterative feature enhancements.

Benefits of NHS EPS Integration

Integrating with NHS EPS via FHIR offers faster, safer, and more reliable prescribing for patients and clinicians. By automating prescription and dispense workflows, you eliminate paper handling, reduce prescription errors, and accelerate patient access to medications.

Dispensing partners can provide real-time dispense updates to NHS App users, improving adherence and visibility. Integration also aligns with national policy goals for electronic repeat dispensing, single-item prescribing, and future FP10 MDA initiatives.

For health tech vendors, EPS FHIR integration boosts interoperability credentials, supports compliance with NHS technical standards, and opens doors to commissioning opportunities across primary and secondary care.

Why choose 6B for NHS EPS API integration?

Proven FHIR expertise – Our team has successfully integrated EPS and Prescription Tracker FHIR APIs, plus DoS lookups and OAuth‑based authentication, ensuring secure, standards-compliant connectivity.


Guidance through NHS onboarding – We assist with Use Case submissions, MoU, SCAL preparation, clinical safety documentation, and tiered onboarding through test and live phases.


Full-lifecycle development – From API implementation and message handling to signing workflows and dispensation tracking, we cover all aspects of prescription creation and management.


Efficient rollout – With sandbox integration and monitored first-of-type deployments built into our process, we help you achieve accelerated go‑live and CATR authorisation .


Strategic interoperability partner – As experienced NHS API integrators, we offer modular architecture that supports future enhancements like electronic repeat dispensing, NHS App notifications, and FP10 MDA forms.

EPS API Integration FAQs

When integrating with the EPS API, common compliance risks include incorrect use of patient identifiers, failure to implement role-based access controls (RBAC), and submitting malformed FHIR bundles. A robust validation and assurance process is essential to meet NHS Digital’s SCAL and clinical safety requirements.

The full EPS API integration lifecycle—from initial onboarding to live deployment—can take up to 10 months, depending on complexity and use case. Partnering with an experienced integrator like 6B can streamline the process through parallel development, early assurance preparation, and pre-validated implementation patterns.

 

Yes. The EPS FHIR API supports complex configurations, including multi-prescriber, multi-site, and cross-organisational workflows. This is especially beneficial for enterprise health tech platforms, pharmacy chains, or multi-location care providers looking to standardise prescription flows under a single integration.

To maximise functionality, EPS API integration should be paired with related NHS APIs such as the Care Identity Service 2 (CIS2) for smartcard authentication, Directory of Services (DoS) for pharmacy lookup, and the Prescription Tracker API for read-only prescription status updates. These enhance operational resilience and patient transparency.

Absolutely. EPS API integration enables mobile-first digital pharmacies, telehealth platforms, and prescribing apps to offer end-to-end digital prescription management. With secure authentication and real-time dispensing updates, it supports a fully remote, compliant medication journey for patients.

Effective EPS API integration requires skills in HL7 FHIR (R4), RESTful API development, secure OAuth2 implementation, and clinical messaging standards. Familiarity with NHS service architecture, particularly NHS smartcard authentication, SCAL documentation, and clinical safety processes, is also critical.

By digitising the prescription workflow, EPS API integration unlocks structured, real-time data on prescribing patterns, dispense timelines, and claim outcomes. This enables health tech vendors to build analytics dashboards, identify operational bottlenecks, and improve medication adherence strategies.

Adopting EPS API integration positions your product for future interoperability upgrades, including support for electronic repeat dispensing, NHS App integration, and evolving prescribing formats like FP10 MDA. It also aligns with NHS England’s long-term digital roadmap and procurement expectations.